04/11/19

拉丁美洲预算削减对科学的巨大打击

abridora_laboratorio vacuna argentina
科学家准备阿根廷出血热疫苗以进行大量生产。版权:国家人类病毒疾病研究所。

速度阅读

  • Budget cuts in science are having a direct impact on Latin American populations
  • 由于缺乏资金,研究未完成
  • Babies in Peru are dying because of the cuts, hospital sources say

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Drastic science cuts are having a devastating impact on Latin American research and costing lives, SciDev.Net correspondents report.

“When my dad died of Argentine hemorrhagic fever I was only six years old. It was a very hard blow for all the family. At that time, there was not an available vaccine,” recalls Juan Sarasola, mayor of Casilda, a town in Argentina’s Santa Fe province.

他补充说:“感谢[Julio] Maiztegui医生和他的团队,制造了一种疫苗,并在我们地区挽救了数千人的生命,那里的发烧是流行的。”

This year, 40 years after the first steps in that vaccine development, its production has been stopped in Argentina due to economic woes. Three machines used to produce it have broken and, amid rising inflation and unpredictable exchange rates, replacing them at a cost of US$267,000 looks unlikely.

“……暂停研究的影响对于社会来说是巨大的,因为我们将失去前景和想法,以实现更美好的未来。”

Hebe Vessuri, social anthropologist

There are currently only 140,000 doses of the vaccine in the country — insufficient to meet the needs of the population for the next year, according to the Maiztegui National Human Viral Diseases Institute. The vaccine is the only one in the world against Argentine hemorrhagic fever and shortages would put around five million people at risk, warn three national medical organisations in a联合声明. Since 2007, the vaccine has been mandatory for Argentineans aged 15 or over who live, work or transit through endemic areas.

1_vacuna Fiebre Hormorragica
A single dose of the Argentine hemorrhagic fever vaccine provides lifelong protection from the disease.
版权:国家人类病毒疾病研究所。

Inside the Maiztegui institute, in Pergamino city, the clock is ticking: even if new equipment for vaccine production appears, the scientists there say they would need about eight months to reset the industry and three more to generate 80,000 doses. That, plus the existing 140,000, they say, could be enough to last up to 2020. The question is, when will the new equipment be up and running?

The National Administration of Laboratories and Health Institutes (ANLIS) in Argentina — the public body which oversees the Maiztegui institute — toldSciDev.Net, that a public procurement process was under way for purchasing the equipment but nobody could be sure whether it would be available this year. ANLIS also insisted that the existing stock of 140,000 doses would cover 2020 demand.

2_FotoProduccionVacunaFHA[72584]
In the final stage of production, bottles are filled with the Argentine hemorrhagic fever vaccine, which includes an attenuated strain of the virus.
版权:国家人类病毒疾病研究所。

Nevertheless, in their joint statement, the Argentine Society of Vaccinology and Epidemiology, the Argentine Society of Virology, and Argentine Association of Microbiology urged national health authorities to act to “assure continuity in vaccine production in Argentina in a timely manner”.

Zika研究受到威胁

In Brazil, there are also threats to scientific progress due to the recently announced budget cuts of thousands of science grants. Research into whether chloroquine, a drug used against malaria and autoimmune diseases, could inhibit Zika virus replication — and associated risks such as microcephaly — could be abandoned as a result.

So far this year (up to 30 September), Brazil has registered 9,813 Zika cases, according to health ministry figures, 447 of which were pregnant women. Two deaths were registered in Paraiba state and there are 1,649 more suspected cases.
遗传学家罗德里戈·布林迪罗(Rodrigo BrindeiroSciDev.Netthat because the drug is already approved for use even in pregnant women and is toxin-free, the cost of continuing with it “is hundreds of times less than investing in new ones”.

3_cloroquina by dennis navarro (bol)
Chloroquine, a drug used against a number of diseases, could prevent replication of Zika, but more research is needed.
Copyright: Dennis Navarro.

他承认:“但是,如果我们继续这样做,我们将无法继续进行研究。”他还指出,自国家科学技术发展理事会(CNPQ)决定由于缺乏资源而决定暂停84,000名研究人员的资金以来,Damocles的剑悬挂在该国成千上万的科学家。

自2016年以来,在巴西科学和技术领域的支出一直在下降,但2019年是过去四年中最糟糕的:科学,技术,创新和传播部的预算约为750,000美元,是2010年的三分之一。

4_UFRJ, microscopio
Budget cuts to Brazil’s universities directly affect research centres such as the molecular virology laboratory of the Federal University of Rio de Janeiro.
Copyright: Washington Castilhos.

These are just two examples of how budget cuts and declining investment in science, technology and innovation are increasingly becoming the norm in the region, with damaging consequences for research and innovation.

“Although some ignorant cynics could argue that nothing will happen if you stop financing science and technology in our region, the impact of suspending research is huge for societies because we would lose direction and ideas for a brighter future,” says Hebe Vessuri, a social anthropologist who won the 2017 Bernardo Houssay award for her work in Argentinean social sciences.

5_entrada UFRJ
A banner at the entrance of the Center of Health Sciences of the Federal University of Rio de Janeiro captures the outrage of the university community before the cuts.
Copyright: Washington Castilhos.

Consuri现在是波哥大哥伦比亚洛杉矶大学的客座教授和委内瑞拉科学研究学院的名誉研究员。她认为,对科学技术的公共投资至关重要,“继续进行预算削减将使我们进入联盟的底层”。

委内瑞拉研究停止了

在委内瑞拉,由于当前的经济和政治危机,研究和创新的可能性实际上不存在。官方政府数据显示,该国在2018年8月至2019年8月之间的过度通货膨胀率为135,379%。而且,经过两次货币重组(从货币中消除零)和15年的交换控制之后,大学无法获得购买试剂或设备的美元。

Additionally, since 2009 public and autonomous universities have received no funding for research, only resources to pay salaries. Facilities and laboratories at these institutions look abandoned and ruined. In some cases, they can only keep going thanks to donations from former fellows now living abroad.

The bioterium at the Central University of Venezuela’s school of medicine, which used to be an elite place for raising animals and scientific trials, now has no animals. A similar situation can be seen at Simón Bolívar University, where 32 years of genetic heritage is at stake.

Biologist Yenis Pérez, who works there, says her project, a vaccine made of recombinant proteins in animals to control parasitic diseases in cattle, is almost paralysed. Researchers only work when they have reagents and the equipment is usable.

Pérez’s research could help prevent humans from becoming infected after consuming contaminated meat and milk. In the past five years, cows in Venezuela have been attacked by parasites, leading to a drop in the production and quality of dairy products and meat.

她说:“我们只有科学家的毅力。”SciDev.Net. “We work with enthusiastic students despite the horrible situation. Even so, it is really hard to make progress.”

6_Bioterio大学委内瑞拉中央,Cienti0301fica triste
A researcher looks sadly at the bioterium facilities of the Central University of Venezuela, completely abandoned.
Copyright: Carmen Victoria Inojosa.

In December 2006, Nieves Canudas, a chemistry professor at Simón Bolívar University, received US$1,302,325 (2,800 million bolívars) after her project won an award from the Science Mission and National Science and Technology Fund. The aim was to develop an ointment that can destroy pathogens from the skin of people suffering from burns.

She used that money to buy equipment and supplies. However, in the past year, Canudas has had to halt her research because of broken equipment which she didn’t have the budget to repair.

“我们没有钱来完成我们的项目。我们需要90,000 bolivars, but now that amount is not enough for our needs. Nor would it cover bioterium trials,” says Canudas.

Rising hyperinflation has worsened the purchasing power of the local currency. In 2017 those 90,000 bolívars represented half of a minimum salary. After the second reconversion in 2018 which took out another five zeros, Canuda couldn’t even buy a metro ticket with that amount.

7_Bioterio Universidad Simo0301n Boli0301var, investigador
The Simón Bolívar University bioterium also looks abandoned and at risk of losing the genetic heritage collected over 32 years.
Copyright: Carmen Victoria Inojosa.

大脑排水风险

One of the most important technological ventures in Brazil, the fourth-generation particle accelerator Sirius, has also been affected by budget cuts.
计划明年通过13个研究站开始其活动,它将仅从其中一个开始。该项目由科学,技术,创新和通信部资助,该部已经投资了4.4亿美元的劳动预算中的3.23亿美元。
Antonio José Roque da Silva, general manager at the National Centre of Energy and Materials Research (CNPEM) and Sirius project, told SciDev.Net that they have received only about 20 per cent of the US$62 million budget approved by Congress for 2019.

Located in the Campinas area of Sao Paulo, the CNPEM/ Sirius facilities have many applications, from studying rocks in oil to raise oil production, to computer tomographies that can improve cancer diagnosis and pave the way to new treatments.

8_lab descuidado
Scientific facilities and laboratories look abandoned and deteriorated.
版权:Zoraida Portillo。

Sirius has been planned since 2012 and developed entirely in Brazil. It is set to be the second active fourth-generation particle accelerator after Sweden’s MAX IV, which opened in 2016. France is building another, expected to be in operation by 2021, while Japan and the United States are also modernising their synchrotron light sources.

物理学家和前CNPEM总统罗杰里奥·德·塞尔奎拉·莱特(Rogerio de Cerqueira Leite)认为,小天狼星是“不仅对巴西和拉丁美洲科学,而且在全球范围内也是超越的飞跃”。他补充说:“这是巴西科学家的自尊心的重要项目,因为我们始终落后于欧洲和美国,而这个项目使巴西与发达国家处于同一地点。”

But he doesn´t know how bad the continuous science budget cuts could be. “Other places in the world are always trying to hire our researchers. If we can’t keep them here, other accelerators in the world will take advantage of the situation, which could be good for some of them but ugly for Brazil,” he explains.

“在不确定的景观中,很难维持高素质的工人。在短期内,有明显的风险打断了研究中心和公司的生产链,”he warns.

9_sirius by CNPEM
巴西国家能源与材料研究中心(CNPEM)的鸟瞰图,该中心设有Sirius项目。
Copyright: CNPEM.

塞尔奎拉·莱特(Cerqueira Leite)担心,重新分配预算可能还不够,并补充说:“如果我们拆除已经拥有的东西,将需要20到30年才能恢复。”

“在不确定的景观中,很难维持高素质的工人。在短期内,有明显的风险打断了研究中心和公司的生产链,”

Rogerio de Cerqueira Leite,物理学家兼前CNPEM总裁

‘General ignorance’

墨西哥Xochimilco Unitiy的大都会自治大学的经济,管理和创新政治研究生的研究生协调员GabrielaDutrénit认为,在所有预算削减和无视科学的背后是人们对科学研究的一般无知和政治家的一般无知的背后,这是科学研究在科学研究中的一般无知社会,我们对此负责 - 不正确地解释它”。
“We have to let society understand the benefits we can get from research, and make politicians understand that it is also true from an economic point of view,” she says, adding: “We need them to see that the consequences are not visible in two days. When somebody cuts a dollar from a specific project you won’t see its effects immediately, but you will in the medium term. Scientists won’t be able to keep on researching and the potential benefits for the whole population simply won’t be there.”

On the other hand, Vessuri notes that the region has a number of unused science and technology facilities, and “we should take advantage of those facilities and use them in a creative way.”

她补充说:“不幸的是,我们认为,当局和政治家的自我贬低过程的一部分是拆除以如此努力建立的能力的严重风险。”

她认为,科学家“没有找到使政客和商人了解科学对我们国家的巨大潜力的方法”。

Babies dying

Perhaps this ignorance is one of the factors that leads certain officials and bureaucrats to divert funds destined to technology and innovation elsewhere when short of resources.

在秘鲁似乎是这种情况,那里有各种公共融资计划来促进技术创新。但是,与此同时,人口无法获得技术,即使是老式的,例如孵化器,监视器和注入泵的早产婴儿,卫生部的Zulema Tomas承认,他们在9月在国家祝贺上发表讲话。

This is the reason why 30 babies died in the first three months of 2019 at the Regional Hospital at Lambayeque in the north of the country, which lacked the budget to repair and buy more incubators, according to hospital sources.

共和国审计长办公室证实,一百万个鞋底(约300,000美元)(占新生儿学预算的一半)已被用来为工人购买圣诞盒子。

11_CIENTIFICA撰写的Hector Vinces-Andina
停止在科学研究中停止投资的结果并没有在一夜之间看到,但从长远来看,社会造成了损失。
版权所有:HéctorVinces,Andean Agency。

在这种绝望的景观中,一些声音呼吁将公共投资在科学和技术方面共同放弃。但是对于Dutrénit来说,“不是时间”。她说:“我认为私人投资无法代替我们国家的公共投资。”

她说,拉丁美洲国家在开发科学和技术基础设施方面还有很长的路要走,以达到维持自己所需的“临界质量”。她总结说:“这不仅需要领导,而且要强调需要投资的发展和社会福利的领域,而且因为公司将始终受到利润的驱动。”

12_incubadoras y mama0301 by la republica
秘鲁的其他目的将注定要维修和购买孵化器的资金被转移。
Copyright: La República newspaper.

This feature was originally produced SciDev.Net’s Latin America and the Caribbean desk with reporting by Valeria Román (Argentina), Washington Castilhos and Meghie Rodrigues (Brazil), Zoraida Portillo (Perú) and Carmen Victoria Inojosa (Venezuela).